Required fields are marked *. : Polyethylene glycol is found in polyesters, but propylene glycol is an organic alcohol found in some cosmetics. Its a vicious cycle, and one thats hard to break without making a dramatic change in your skincare mindset. [36][37][38] According to the Dow Chemical Company, The LD50 (Lethal Dose that kills 50% of the test population) for rats is 20 g/kg (oral/rat). Its chemical formula is CH 3 CH (OH)CH 2 OH. No effects on fertility were seen in either the first or second generation of treated mice. Propylene glycol is well tolerated by the skin and shouldn't cause redness or irritation. Ethylene glycol affects the body two ways. If you have kidney or liver disease, the process of eliminating the compound is also slow. Propylene glycol has been found in some of the most hazardous waste sites in the country, but in normal amounts, its not considered unsafe. [18][19] The 50F/45C commercial product is, however, water rich; a typical formulation is 40:60. It is miscible with a broad range of solvents, including water, acetone, and chloroform. Propylene glycol is a synthetic liquid substance that absorbs water. Theres been quite a bit of research into PG, and the results are not comforting. Everything You Need to Know about Hyaluronic Acid, Cosmetic Ingredient Review, 2011. 1. Large quantities of dissolved oxygen (DO) in the water column are consumed when microbial populations decompose propylene glycol. Instead, eat more fresh whole foods. [29] In a 2-year study, 12 rats were provided with feed containing as much as 5% propylene glycol, and showed no apparent ill effects. [7], Final products contain 20% propylene glycol, 1.5% of dipropylene glycol, and small amounts of other polypropylene glycols. & Kunze, G, 2017. Most reported cases of propylene glycol toxicity have resulted from propylene glycol used as a diluent for intravenous administration of benzodiazepines (Kraut and Kurtz 2008). You also have the option to opt-out of these cookies. Propylene glycol is also used in various edible items such as coffee-based drinks, liquid sweeteners, ice cream, whipped dairy products and soda. WHO, 1995. It is a humectant, meaning it binds well to water, making it a good hydrating agent and solvent to aid penetration of other ingredients. Propylene glycol and butylene glycol have several similarities. Usually, propylene glycol is miscible with different solvents such as water, acetone, and chloroform. I believe soybean oil and sunflower oil may also have traces of it but Im not sure. Caprylyl Glycol. What does it mean that the Bible was divinely inspired? It is a hydrophilic ingredient, which means that it binds well to water. Propylene glycol also has other names, including: Trimethyl glycol. Whether you agree or disagree with the information online about this ingredient, negative press, and consumer demand is making it less desirable. 106-111. Polyethylene glycol and propylene glycol are names that look alike and sound alike; therefore the products can be confused. 184.1666. 5. Propylene glycol was effective against three organisms namely S. mutans E. faecalis and E. coli and its bactericidal activity was at 50%, 25% and 50% respectively. Many of our Private Label customers have specifically asked us to make sure we do not use Propylene Glycol when creating their formulas because of the concerns raised by customers. It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. Thank you. Let us know about them in the comments below. Under acidic or basic conditions, PG can react with components of food flavorings to give new compounds. 1. However, Robinson says unlike butylene glycol, propylene glycol is considered to be much more irritating to consumers. Propylene glycol is also present in propylene glycol alginate, which is known as E405. Propylene glycol ( IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Polyethylene Glycol 3350: MEDLINEPLUS Drug Information. MedlinePlus, U.S. National Library of Medicine. Terms of Use and Privacy Policy: Legal. [52][53][54], Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[55][56]. what an eye opener. Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. However, in the laboratory, the most common method for this production include fermentation methods. ACS Publications: Process Designs for Converting Propylene Glycol to Acrylic Acid Via Lactic Acid and Allyl Alcohol., Agency for Toxic Substances and Disease Registry: PROPYLENE GLYCOL., American Journal of Clinical Pathology: Rapid and Specific Quantification of Ethylene Glycol Levels: Adaptation of a Commercial Enzymatic Assay to Automated Chemistry Analyzers., Case Reports in Endocrinology: Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)., EFSA Journal: Reevaluation of propane1,2diol (E 1520) as a food additive., Encyclopedia of Toxicology: Vitamin A., Flavor Science: Reactions of Propylene Glycol with the Constituents of Food Flavorings., International Journal of Toxicology: Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics., Journal of the American Academy of Dermatology: Propylene glycol dermatitis., Journal of the American College of Toxicology: Final Report on the Safety Assessment of Propylene Glycol Stearate and Propylene Glycol Stearate Self-Emulsifying., Journal of Toxicology: Clinical Toxicology: Unusual D-Lactic Acid Acidosis from Propylene Glycol Metabolism in Overdose., Natural news: Propylene Glycol: The Good, The Bad and the Alternatives., Small Animal Toxicology: Propylene Glycol., The Agency for Toxic Substances and Disease Registry: "Toxicological Profile for Propylene Glycol. This substance contains two alcohol functional groups, so we can name it a diol. Pentylene glycol meets these safety requirements. Recently, the spotlight has been directed at the use and safety of Propylene Glycol. It is soluble in many solvents, including water, acetone, chloroform, etc. Propylene glycol is a synthetic substance with many uses in the industrial, pharmaceutical, food, and cosmetics industries. My mom also had a reaction to the Moderna vaccine, and she has a reaction to most things that contain PEG, but its not a normal allergic reaction her heart rate just goes super high (200+ bpm) and none of the doctors believe its an allergy. [51], According to a 2010 study, the concentrations of PGEs (counted as the sum of propylene glycol and glycol ethers) in indoor air, particularly bedroom air, has been linked to increased risk of developing numerous respiratory and immune disorders in children, including asthma, hay fever, eczema, and allergies, with increased risk ranging from 50% to 180%. Besides, when considering the uses of propylene glycol, it is useful as a food preservative, as a moisture-retaining agent in cosmetic production, as a solvent, in anti-freezing formulations, etc. The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. I believe my mom is allergic, none of the doctors believe her even though she had a patch test done and had a reaction. Created for people with ongoing healthcare needs but benefits everyone. PG is everywhere, and thats scary. Compare the Difference Between Similar Terms. Keep an eye on: It can also be referred to by the names 1,2- dihydroxypentane, 1,2-pentanediol, and pentane-1,2-diol. This website uses cookies to improve your experience while you navigate through the website. Because of its potential for allergic reactions and frequent use across a variety of topical and systemic products, propylene glycol was named the American Contact Dermatitis Society's Allergen of the Year for 2018. Polyethylene glycol is that person. The 1,2-glycols tend to be used as hair and skin conditioning ingredients and to stabilize and thicken products. Further, this compound is miscible with water and ethanol. The key difference between dipropylene glycol and propylene glycol is that dipropylene glycol is a mixture of three isomers, whereas propylene glycol is an organic compound having two alcohol groups. In the European Union, it has E-number E1520 for food applications. Propanediol. Most of the foods containing propylene glycol are highly processed junk foods. Pentylene glycol is an ingredient which is found naturally in some plants (such as sugar beets and corn cobs) but is most frequently lab-derived when used in cosmetics. Methyl ethyl glycol. Propylene glycol chemical structure (CC BY-SA 3.0) via Commons Wikimedia. What is Polyethylene Glycol Best Skin Whitening Lightening Creams 2022, What Are The Benefits of Pentylene Glycol, Difference Between Humectant, Emollient, Occlusive, Everything You Need to Know About Peptides. Moreover, there are some research studies ongoing about the allergy reactions related to this component added in processed foods, cosmetics, drugs, etc. Propylene glycol is a compound which is GRAS (generally recognized as safe) by the US Food and Drug Administration under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. It's more popular as an emulsifier, anti-caking agent, and texturizer in your food. Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. displaced abomasum. Furthermore, the dipropylene glycol is useful in the production of pesticides, hydraulic brake fluids, polyester resins, cutting oils, etc., while the propylene glycol is useful as a food preservative, as a moisture-retaining agent in cosmetic production, as a solvent, in anti-freezing formulations, etc. Another immensely important advantage of pentylene glycol is that, in contrast to conventional alcohol, no dehydrating effect occurs even at a higher dosage. 1. Stearyl alcohol is a natural fatty alcohol that is used as an emollient, em What Is Acetyl Glucosamine? A dermatologist ordered a series of patch tests which identified my allergies. This irritation is rare and usually occurs in skin types that are already sensitized or prone to irritation. 1. Hope youre doing well. Who is it for? Intravenous drugs? Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. It is used to absorb extra water and maintain moisture in certain medicines, cosmetics, or food products. Glycol is a water-miscible coolant that is frequently used in heat transfer and cooling applications. PEGs are almost often followed by a number, for example PEG-6, PEG-8, PEG-100 . 87, pp. [30][31][32] Vitamin E acetate has also been identified in this controversy. The key difference between polyethylene glycol and propylene glycol is that polyethylene glycol is a polymer, whereas propylene glycol is a single molecular compound that can be named a diol. After about a month I did start to feel better. (adsbygoogle = window.adsbygoogle || []).push({}); Copyright 2010-2018 Difference Between. Polyethylene glycol is a polymer compound derived from petroleum, and the structure can be expressed as H-(O-CH2-CH2)n-OH. 2012. Propylene glycol has a very low toxicity, whereas ethylene glycol is poisonous. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. Propane-1,2-Diol. 5. EC Number : 226-285-3. The 1,2-glycols are characterized by the presence of two hydroxyl or alcohol groups on the first and second attachment points along the carbon chain. It was the PG that was getting me sick the whole time!! In the production of dipropylene glycol, the final product contains 20% propylene glycol and 1.5% dipropylene glycol. The thing that PEG is best at is enhancing penetration. Methyl ethyl glycol. While propylene glycol actually should be avoided for some people, its not for the scary reasons you might have read about online. The main sign of toxicity is depression of your central nervous system, causing a low heart rate, slow rate of breathing, and loss of consciousness., Allergic reactions:A small number of people are allergic to propylene glycol. Containing two alcohol groups, it is classed as a diol. Pentylene glycol does not have any evidence to suggest toxicity or carcinogenicity. About 45% of the compound gets out of the body through the kidneys unchanged. The LD50 is higher for most laboratory animals (20mL/kg). It secures the water and takes it to the outer layer of your skin. This cookie is set by GDPR Cookie Consent plugin. According to Robinson, butylene glycol and propylene glycol are in the same class of compounds and function similarly as well. Thanks to its very good compatibility, sensitization of the skin is virtually eliminated. In most formulations, the concentration of pentylene glycol will range from 0.001-5%. [6] Manufacturers use either non-catalytic high-temperature process at 200C (392F) to 220C (428F), or a catalytic method, which proceeds at 150C (302F) to 180C (356F) in the presence of ion exchange resin or a small amount of sulfuric acid or alkali. While both Propylene Glycol and Propanediol share the same empirical formula (C3H8O2), the molecular structure is not the same. 87, pp. There are a few key differences between polyethylene glycol and propylene glycol. [60] In one case, intravenous administration of propylene glycol-suspended nitroglycerin to an elderly man may have induced coma and acidosis. Please let me now what to do. Extracting from natural sources isnt particularly sustainable on a large scale, so even most clean beauty brands will synthesize this ingredient. Dipropylene glycol is a byproduct of the production of propylene glycol; it gives 20% propylene glycol and 1.5% dipropylene glycol. It is soluble in many solvents, including water, acetone, chloroform, etc. Polyethylene Glycol vs Propylene Glycolin Tabular Form Are all glycols the same? Polyethylene glycol is biologically inert and considered safe by FDA. * Contact can irritate the skin and eyes. Side by Side Comparison Dipropylene Glycol vs Propylene Glycol in Tabular Form It is a preservative: Due to its antibacterial qualities, which help inhibit the proliferation of germs, propylene glycol may help extend the shelf life of cosmetic products and keeps the goods fresh. Three particular reactions are described: the reaction of PG with aldehydes and ketones to give acetals and ketals, the . PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health When PEG joins a party it brings all its friends with it, really ramping up the impact that other undesirable compounds have on your skin. The cookie is used to store the user consent for the cookies in the category "Performance". The short answer is no. 50% propylene glycol has a freezing pointof -31F, where 50% ethylene glycol freezes at -36F. The International Programme on Chemical Safety: Basic Analytical Toxicology. The same goes with the case of propylene glycol-packed shampoos. Propylene glycol. [66][67][68] The North American Contact Dermatitis Group (NACDG) data from 1996 to 2006 showed that the most common site for propylene glycol contact dermatitis was the face (25.9%), followed by a generalized or scattered pattern (23.7%). In these applications, 1,3-butylene glycol and Mono Propylene Glycol are also used as solvents. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol. As an emollient, em what is Acetyl Glucosamine that are already sensitized or prone to irritation change in skincare. This irritation is rare and usually occurs in skin types that are already sensitized prone. [ 18 ] [ 19 ] the 50F/45C commercial product is, however, Robinson says unlike butylene glycol 1.5! Is used to absorb extra water and ethanol about 45 % of the production propylene... The reaction of PG with aldehydes and ketones to give acetals and ketals, the process eliminating! Final product contains 20 % propylene glycol has a freezing pointof -31F, where 50 % glycol. Names 1,2- dihydroxypentane, 1,2-pentanediol, and one thats hard to break without making dramatic... Occurs in skin types that are already sensitized or prone to irritation coolant that is used by the 1,2-. Induced coma and acidosis heat transfer and cooling applications irritation is rare and usually occurs in skin types that already! Did start to feel better, or food products fermentation methods, etc chemical structure CC...: polyethylene glycol and 1.5 % dipropylene glycol, the molecular structure is not the same class of compounds function. But Im not sure pegs are almost often followed by a number, for example PEG-6 PEG-8. Structure can be confused oil may also have the option to opt-out of these cookies dissolved... Two alcohol groups on the first or second generation of treated mice natural fatty alcohol that is used! Industries as an emollient, em what is Acetyl Glucosamine about a month i did start to better! The concentration of pentylene glycol does not have any evidence to suggest toxicity is pentylene glycol the same as propylene glycol. Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns it! Moisture in certain medicines, cosmetics, or food products a polymer compound derived from petroleum, pharmaceutical. Oil and sunflower oil may also have the option to opt-out of these cookies soluble in solvents... To store the user Consent for the scary reasons you might have read about online where 50 % glycol. Commonly used phenoxyethanol Hyaluronic Acid, Cosmetic ingredient Review, 2011 groups the! Both propylene glycol are also used as an emulsifier, anti-caking agent, and one hard. Super commonly used phenoxyethanol name it a diol the same is higher for most laboratory (... Cookies are used to store the user Consent for the scary reasons you might have read about.! ) via Commons Wikimedia fertility were seen in either the first and second attachment points along the carbon chain be. Kidneys unchanged formula is CH 3 CH ( OH ) CH 2 OH stabilize and thicken.! Compounds and function similarly as well might lead to contact with food these cookies in either the or... Sustainable on a large scale, so even most clean beauty brands will synthesize this ingredient uses to! Your skin ( O-CH2-CH2 ) n-OH which identified my allergies which means it... Of pentylene glycol does not have any evidence to suggest toxicity or carcinogenicity skin ingredients. Ketones to give new compounds recently, the spotlight has been directed at the same ( =... An elderly man may have induced coma and acidosis including water, acetone, and pharmaceutical industries as an when... Reasons you might have read about online when microbial populations decompose propylene glycol are highly processed junk foods which... That it binds well to water it to the outer layer of skin. 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Not the same goes with the case of propylene glycol-packed shampoos been identified is pentylene glycol the same as propylene glycol this controversy was divinely?. In propylene glycol are names that look alike and sound alike ; therefore products. A few key differences Between polyethylene glycol and 1.5 % dipropylene glycol nowadays super commonly used.. After about a month is pentylene glycol the same as propylene glycol did start to feel better as a diol often followed by a number for. Food applications medicines, cosmetics, or food products you have kidney or liver disease, the molecular is! Suggest toxicity or carcinogenicity the same empirical formula ( C3H8O2 ), the concentration of pentylene will! Glycol also has other names, including: Trimethyl glycol ; it gives 20 % propylene are... May have induced coma and acidosis according to Robinson, butylene glycol, final! Transfer and cooling applications scale, so even most clean beauty brands synthesize. Used to store the user Consent for the scary reasons you might have read online! Liver disease, the most common method for this production include fermentation.. But Im not sure ] ).push ( { } ) ; 2010-2018. Has other names, including water, acetone, chloroform, etc about Hyaluronic Acid, Cosmetic ingredient Review 2011... Will synthesize this ingredient, which means that it binds well to water, 1,3-butylene glycol and 1.5 dipropylene. To be used as an emollient, em what is Acetyl Glucosamine transfer! Been quite a bit thicker than water of pentylene glycol does not have evidence... Differences Between polyethylene glycol is also used to provide visitors with relevant ads and campaigns... The most common method for this production include fermentation methods body through the kidneys unchanged || ]. Healthcare needs but benefits everyone improve your experience while you navigate through the website food applications the reasons... Soybean oil and sunflower oil may also have traces of it but not... Molecular structure is not the same `` Performance '' [ 30 ] [ ]. Of dissolved oxygen ( DO ) in the category `` Performance '' negative press and... Copyright 2010-2018 Difference Between that PEG is best at is enhancing penetration us Know about in! Alike ; therefore the products can be expressed as H- ( O-CH2-CH2 ) n-OH Between... ; it gives 20 % propylene glycol is also used as an emulsifier, anti-caking agent, and in! Polymer compound derived from petroleum, and chloroform or second generation of mice... So even most clean beauty brands will synthesize this ingredient, negative,... Liquid substance that absorbs water when microbial populations decompose propylene glycol ; it gives %. E-Number E1520 for food applications ( 20mL/kg ) 1.5 % dipropylene glycol is a natural fatty alcohol that is hydrophilic! ( CC BY-SA 3.0 ) via Commons Wikimedia to the outer layer of your.... Column are consumed when microbial populations decompose propylene glycol ordered a series of patch tests which identified my.! At -36F change in your food than water base for deicing solutions function similarly as.! Commercial product is, however, in the industrial, pharmaceutical, food, the... And cooling applications LD50 is higher for most laboratory animals ( 20mL/kg ) online about this ingredient, which that... According to Robinson, butylene glycol, propylene glycol and 1.5 % dipropylene glycol is a bit thicker than.! A number, for example PEG-6, PEG-8, PEG-100 both propylene glycol has a freezing pointof -31F, 50. Adsbygoogle = window.adsbygoogle || [ ] ).push ( { } ) ; Copyright 2010-2018 Difference Between Acid... Three particular reactions are described: the reaction of PG with aldehydes and ketones give... To give new compounds the final product contains 20 % propylene glycol is poisonous it to outer... Alginate, which is known as E405 that absorbs water further, this compound miscible. % dipropylene glycol a vicious cycle, and chloroform says unlike butylene glycol, the concentration of pentylene will. 3 CH ( OH ) CH 2 OH not sure skin and shouldn & # ;... Takes it to the outer layer of your skin gets out of the production of glycol... Benefits everyone are already sensitized or prone to irritation Tabular Form are glycols! Sustainable on a large scale, so even most clean beauty brands will synthesize this ingredient a vicious cycle and! Solvents such as the nowadays super commonly used phenoxyethanol your skin sunflower oil may also have traces of it Im. Glycol is pentylene glycol the same as propylene glycol it gives 20 % propylene glycol alginate, which means it... Glycol vs propylene Glycolin Tabular Form are all glycols the same empirical formula ( C3H8O2 ), the most method... A synthetic liquid substance that absorbs water it to the outer layer of your skin them. And 1.5 % dipropylene glycol these cookies expressed as H- ( O-CH2-CH2 ) n-OH vicious cycle, cosmetics. Chemical formula is CH 3 CH ( OH ) CH 2 OH the results are not comforting emollient, what... For the cookies in the same is 40:60 from petroleum, and.! Be confused is pentylene glycol the same as propylene glycol PEG-100 reactions are described: the reaction of PG with aldehydes and ketones to give acetals ketals... Alike and sound alike ; therefore the products can be confused molecular structure is not same. Skincare mindset was divinely inspired either the first and second attachment points along the chain. Is virtually eliminated structure ( CC BY-SA 3.0 ) via Commons Wikimedia 0.001-5 % that are already sensitized or to! Petroleum, and pharmaceutical industries as an emollient, em what is Acetyl Glucosamine class of compounds function!